Duke University, Durham

'Computer-chemistry' gives new insight into the puzzle of cell division

Published in Lab Business Week, January 1st, 2006

Duke University biochemists aided by Duke computer scientists and computational chemists have identified the likely way two key enzymes dock in an intricate three-dimensional puzzle-fit to regulate cell division. Solving the docking puzzle could lead to anticancer drugs to block the runaway cell division behind some cancers, said the researchers.

Significantly, their insights arose not just from meticulous biochemical studies, but also from using sophisticated simulation techniques to perform "chemistry in the computer."

In a paper published online in the journal Biochemistry, members of the interdisciplinary collaboration described how they...

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Source: Lab Business Week (2006-01-01)

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