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Medical College of Wisconsin

Angiostatin may treat pathological corneal neovascularization

Published in Lab Business Week, January 1st, 2006

Angiostatin may treat pathological corneal neovascularization.

According to recent research from the United States, "maintenance of avascularity of the normal cornea and control of neovascularization during wound healing depend on a balance of angiogenic and antiangiogenic factors. The purpose of this paper is to determine the ability of corneal cells to convert plasminogen to angiostatins and to compare these products with those made by intact corneas."

"Reverse transcriptase-polymerase chain reaction was performed using plasminogen specific primers and the generated cDNA was sequenced. The proteins in corneal extracts, cornea conditioned medium,...

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