St. Mary's Hospital, Rochester
Leptin alters endothelial progenitor cell functionality
Published in Lab Business Week, January 8th, 2006
"Circulating EPCs may be involved in the maintenance of vascular homeostasis and their impairment may be conducive to vascular disease. We studied the role of an adipocyte-derived hormone, leptin, in the regulation of human EPC function," scientists in the United States report.
"EPCs were grown from human circulating mononuclear cells. The presence of the leptin receptor and the functional effects of leptin in EPCs were investigated. EPCs stained positive for endothelial cell markers (Flk-1 and Tie-2 receptors) and the hematopoietic CD34 marker. The presence of the long form of the leptin...
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Source: Lab Business Week (2006-01-08)
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