Alexion Pharmaceuticals, Inc.

Patient treatment completed in phase III TRIUMPH trial of eculizumab in PNH patients

Published in Lab Business Week, February 5th, 2006

Alexion Pharmaceuticals, Inc., (ALXN) has completed treatment of the final patient in the pivotal phase III TRIUMPH efficacy trial of eculizumab in patients with the chronic orphan blood disorder Paroxysmal Nocturnal Hemoglobinuria (PNH), a rare form of hemolytic anemia characterized by destruction of red blood cells by the immune system.

In accordance with the trial's design, eligible patients were randomized to receive either eculizumab or placebo in a 6-month treatment phase. Eculizumab is a monoclonal antibody drug that selectively blocks terminal complement, a part of the immune system that is implicated in PNH red blood cell destruction. There currently is no drug...

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Source: Lab Business Week (2006-02-05)

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