University of Michigan
Gemcitabine enhances ganciclovir-mediated bystander cytotoxicity
Published in Lab Business Week, February 12th, 2006
"To improve bystander cell killing with HSV-TK/GCV, we have utilized dFdCyd to reduce endogenous dGTP, which competes with GCVTP for incorporation into DNA," wrote P.D. Boucher and colleagues, University of Michigan.
"In this study we demonstrate the ability of dFdCyd to enhance GCV-mediated bystander cytotoxicity in cultured SW620 human colon carcinoma cells as well as in a murine xenograft model."
The authors wrote, "In vitro, dFdCyd reduced cellular dGTP levels and produced a fourfold increase in...
Want to see the full article?
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Lab Business Week
Source: Lab Business Week (2006-02-12)
More Articles from Lab Business Week
- Acadia Pharmaceuticals, Inc.
Pharmaceutical company reports additional $10M equity investment by Sepracor - Adlyfe, Inc.
Protein detection technology developer secures $3.3M in series A round - Advanced BioPhotonics, Inc.
Imaging company closes on second financing milestone - Akorn, Inc.
Ophthalmic drug developer retires series A preferred stock - Aksys, Ltd.
Dialysis systems developer reports $20M stock purchase agreement - Allergan, Inc.
Regulatory approvals granted by Germany, Spain for exchange offer with Inamed Corp. - More from this issue of Lab Business Week
NewsRx is Social
Follow us on your favorite social network by clicking on a button below:
Top Medical Newsletters
Awards
Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005
Facts & Stats
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.
- Google 2010 PageRank: #2 Among Top Health News and Media Publications
- Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
- Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
- Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry
