University of Padua
Arrhythmogenic right ventricular cardiomyopathy is linked to mutations in desmoglein-2 gene
Published in Lab Business Week, April 30th, 2006
According to recent research published in the journal Circulation, "Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited cardiomyopathy characterized by progressive myocardial atrophy with fibrofatty replacement. The recent identification of causative mutations in plakoglobin, desmoplakin (DSP), and plakophilin-2 (PKP2) genes led to the hypothesis that ARVC is due to desmosomal defects. Therefore, desmoglein-2 (DSG2), the only desmoglein isoform expressed in cardiac myocytes, was screened in subjects with ARVC."
K. Pilichou and...
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Source: Lab Business Week (2006-04-30)
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