Evanston NW Healthcare Research Institute
Breast cancer cells find an adenovirus cytotoxic
Published in Lab Business Week, April 30th, 2006
"In recent years, adenoviruses that selectively replicate in tumor cells have been developed. However, there is a tremendous need to improve their anticancer efficacy," scientists writing in the journal Molecular Cancer Therapeutics report.
"We wish to investigate whether a strategy that combines the oncolytic effects of an adenoviral vector with simultaneous expression of soluble form of transforming growth factor-beta type II receptor (sTGF beta RII) offers a therapeutic advantage. We chose to target TGF-betas because they play a pivotal role...
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Source: Lab Business Week (2006-04-30)
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