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Stroke

Symptomatic stroke involves increased expression of genes controlling aspects of carotid plaques

Published in Lab Business Week, May 21st, 2006

According to a study from the United States, symptomatic stroke involves the increased expression of genes that control ionic homeostasis, second messenger signaling and metabolism in the carotid plaques.

"The molecular mechanisms that render a carotid atherosclerotic plaque symptomatic have not yet been identified," wrote R. Vemuganti and colleagues, University of Wisconsin.

They explained, "Using an Affymetrix Human GeneChip set, we analyzed the gene expression patterns of 44,862 mRNA transcripts in surgically removed carotid artery plaques from six patients with symptomatic stroke and four non-symptomatic patients."

"The age,...

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