Harvard University
Research from the United States and Portugal add new data to herpes body of knowledge
Published in Lab Business Week, May 21st, 2006
Study 1: Kaposi's sarcoma-associated herpesvirus interferon regulatory factor 1 inhibits the ATM/p53 signal transduction pathway.
"Infected cells recognize viral replication as a DNA damage stress and elicit the ataxia telangiectasia-mutated (ATM)/p53-mediated DNA damage response signal transduction pathway as part of the host surveillance mechanisms, which ultimately induces the irreversible cell cycle arrest and apoptosis.
"Viruses have evolved a variety of mechanisms to counteract this host intracellular innate immunity. Kaposi's sarcoma-associated...
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Source: Lab Business Week (2006-05-21)
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