University College London, U.K.

Researchers from the United Kingdom and United States report details of new studies and findings in the area of HIV/AIDS

Published in Lab Business Week, September 24th, 2006

HIV/AIDS data are the focus of recent research from the United Kingdom and United States.

Study 1: Cyclophilin A alters HIV-1 sensitivity to a TRIM5 alpha-independent innate immune pathway.

"TRIM5 alpha is an important mediator of antiretroviral innate immunity influencing species-specific retroviral replication. Here we investigate the role of the peptidyl prolyl isomerase enzyme cyclophilin A in TRIM5 alpha antiviral activity.

"Cyclophilin A is recruited into nascent human immunodeficiency virus type 1 (HIV-1) virions as well as incoming HIV-1 capsids, where it isomerizes an exposed proline residue," wrote investigators in...

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Source: Lab Business Week (2006-09-24)

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