Gothenburg University, Sweden

Hyperinsulinemia lowered AT1a-to-AT2 ratio and raised MEK-ERK1/2 and S6K1 pathway activity

Published in Lab Business Week, September 24th, 2006

Hyperinsulinemia lowered AT1a-to-AT2 ratio and raised MEK-ERK1/2 and S6K1 pathway activity related to hypertrophy.

In a recent article published in the American Journal of Physiology - Heart and Circulatory Physiology, scientists in Sweden conducted a study "to investigate the association between hyperinsulinemia and cardiac hypertrophy, we treated rats with insulin for 7 wk and assessed effects on myocardial growth, vascularization, and fibrosis in relation to the expression of angiotensin II receptors (AT-R)."

"We also characterized," continued A.M. Samuelsson and colleagues, Gothenburg University, "insulin signaling pathways believed to...

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Source: Lab Business Week (2006-09-24)

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