University of Michigan, U.S.

Comparative oncogenomics used for cancer gene discovery

Published in Lab Business Week, October 1st, 2006

Comparative oncogenomics could be used to identify cancer genes involved in oncogenesis and metastasis.

"With the proliferation of high-throughput technologies to profile the cancer genome, methods to distinguish causal from bystander genetic events are needed," scientists in the United States reported.

"Two recent reports by Zender et al. and Kim et al. in Cell use genetically defined mouse models to serve as biological filters to mine the human cancer genome. Integration of high-resolution copy number profiles of mouse tumor models and human tumors identified cIAP1 and Yap as oncogenes in human hepatocellular carcinoma, while NEDD9 was...

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Source: Lab Business Week (2006-10-01)

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