Case Western Reserve University, U.S.

Regulatory elements coordinate expression of a nicotinic receptor gene cluster

Published in Lab Business Week, October 1st, 2006

According to recent research from the United States, shared long-range regulatory elements coordinate expression of a gene cluster encoding nicotinic receptor heteromeric subtypes.

"The nicotinic acetylcholine receptor (nAChR) beta 4/alpha 3/alpha 5 gene cluster encodes several heteromeric transmitter receptor subtypes that are essential for cholinergic synaptic transmission in adrenal gland, autonomic ganglia, pineal gland, and several nuclei in the central nervous system. However, the transcriptional mechanisms coordinating expression of these subunit genes in different cell populations are unknown," wrote X.H. Xu and colleagues, Case School of Medicine.

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Source: Lab Business Week (2006-10-01)

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