Published in Lab Business Week, November 5th, 2006
Study 1: Interleukin-7 induces HIV replication in primary naive T cells through a nuclear factor of activated T cell-dependent pathway.
"Interleukin (IL)-7 plays several roles critical to T cell maturation, survival, and homeostasis. Because of these functions, IL-7 is under investigation as an immune-modulator for therapeutic use in lymphopenic clinical conditions, including HIV.
"We reported that naive T cells, typically not permissive to HIV, can be productively infected when pretreated with IL-7. We evaluated the mechanism by which IL-7-mediates this...
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