Escherichia coli
Reports from Wellcome Trust Research Laboratories highlight recent research in escherichia coli
Published in Lab Business Week, November 19th, 2006
Research findings, "Structures of R- and T-state Escherichia coli aspartokinase III. Mechanisms of the allosteric transition and inhibition by lysine," are discussed in a new report. According to a study from Oxford, the United Kingdom, "Aspartokinase III (AKIII) from Escherichia coli catalyzes an initial commitment step of the aspartate pathway, giving biosynthesis of certain amino acids including lysine. We report crystal structures of AKIII in the inactive T-state with bound feedback allosteric inhibitor lysine and in the R-state with aspartate and ADP."
"The structures reveal an unusual configuration for the regulatory ACT domains, in which ACT2 is inserted...
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Source: Lab Business Week (2006-11-19)
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