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Head and Neck Cancer

Merck KGaA: Erbitux Meets Primary Endpoint in First-Line Phase III Head and Neck Cancer Study

Published in Lab Business Week, April 29th, 2007

Merck KGaA announced today that a first-line Phase III study of Erbitux(R) (cetuximab) combined with platinum-based chemotherapy met the primary endpoint of increasing overall survival in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck (SCCHN). This randomized European trial, known as EXTREME (ErbituX in first line Treatment of REcurrent or MEtastatic head & neck cancer), studied more than 400 patients treated with Erbitux in combination with either cisplatin plus 5-fluorouracil (5-FU) or carboplatin plus 5-FU compared with patients treated with cisplatin plus 5-FU or carboplatin plus 5-FU alone.

"Recurring and metastatic head and...

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