Vascular Disease
Lexicon Develops Antibodies That Lower Triglycerides and Cholesterol as Potential New Therapy for Heart Disease
Published in Lab Business Week, July 22nd, 2007
Lexicon Pharmaceuticals, Inc. (NASDAQ:LXRX) reported results from preclinical research demonstrating that antibodies directed to a potential new target, angiopoietin-like protein 4 (ANGPTL4), rapidly lower triglycerides and cholesterol. Research suggests that a monoclonal antibody (mAb) targeting ANGPTL4 may have therapeutic application in the treatment of cardiovascular disease. The results appeared in an article, entitled "Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 knockout mice," published in the July 10, 2007 edition of the journal Proceedings of the National Academy of Sciences.
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Source: Lab Business Week (2007-07-22)
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