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Research reports on life sciences from The Jackson Laboratory provide new insights

Published in Lab Business Week, October 7th, 2007

Researchers detail in "C. elegans sequences that control trans-splicing and operon pre-mRNA processing," new data in life sciences. According to recent research from the United States, "Many mRNAs in Caenorhabditis elegans are generated through a trans-splicing reaction that adds one of two classes of spliced leader RNA to an independently transcribed pre-mRNA. SL1 leaders are spliced mostly to pre-mRNAs from genes with outrons, intron-like sequences at the 5'-ends of the pre-mRNAs."

"In contrast, SL2 leaders are nearly exclusively trans-spliced to genes that occur downstream in polycistronic pre-mRNAs produced from operons. Operon pre-mRNA processing requires...

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