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Cell Biology

Scientists at Beatson Laboratories target cell biology

Published in Lab Business Week, October 21st, 2007

Current study results from the report, 'Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complex,' have been published. According to a study from Bearsden, the United Kingdom, "Networks of actin filaments, controlled by the Arp2/3 complex, drive membrane protrusion during cell migration. How integrins signal to the Arp2/3 complex is not well understood."

"Here, we show that focal adhesion kinase (FAK) and the Arp2/3 complex associate and colocalize at transient structures formed early after adhesion. Nascent lamellipodia, which originate at these structures, do not form in FAK-deficient cells, or in cells in which FAK mutants...

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