Immunology
L-Proline Stabilizer Used in the Intravenous Immunoglobulin Product Privigen(R) Shows No Neurological Side Effects Compared with Currently Used Stabilizers
Published in Lab Business Week, December 2nd, 2007
CSL Behring announced new data today that demonstrates that L-proline causes no neurological effects, including convulsive behaviour and spatial learning and memory, even at high doses, when compared with glycine, which is used in many current intravenous immunoglobulin (IVIg) products. L-proline is used as stabilizer in the new Immune Globulin Intravenous (human) 10% product (Privigen(R)). The data were presented at the American Congress of Allergy, Asthma and Immunology (ACAAI) in Dallas, Texas.
The study aimed to assess the neurological safety of glycine and L-proline in two separate tests using rats. The neurobiological state was evaluated using the Irwin test,...
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Source: Lab Business Week (2007-12-02)
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