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Scientists at Merck & Company, Inc. detail research in life sciences

Published in Lab Business Week, March 23rd, 2008

Current study results from the report, 'Genetic variation within the beta1-adrenergic receptor gene results in haplotype-specific expression phenotypes,' have been published. According to recent research published in the Journal of Cardiovascular Pharmacology, "Cardiac beta1-adrenergic receptor (beta1AR) responsiveness in heart failure exhibits interindividual variation that may be attributable to polymorphisms of the intronless beta1AR gene. We sought to ascertain the polymorphisms of the full-length gene and the specific combinations of polymorphisms (haplotypes) in two reference populations."

"Using whole-gene transfections, we established the impact of...

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