New cancer therapy research from Beatson Laboratories outlined

New investigation results, 'Telomere dysfunction is related to the intrinsic radio-resistance of human oral cancer cells,' are detailed in a study published in Oral Oncology. "Evidence from telomerase-deficient mice strongly suggests that dysfunctional short telomeres affect cellular radio-sensitivity but this idea has yet to be extensively tested in relevant human cancer types such as oral squamous cell carcinomas (OSCCs), which are frequently treated by radiotherapy. The OSCC line BICR7 has low levels of telomerase activity, short telomeres and high levels of telomere dysfunction (judged by a high level of anaphase bridges); whereas the BICR6 line has high levels of telomerase and...

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