Gene Therapy
Research in the area of gene therapy reported from Cold Spring Harbor Laboratory
Published in Lab Business Week, May 11th, 2008
Fresh data on gene therapy are presented in the report 'OSTM1 regulates beta-catenin/Lef1 interaction and is required for Wnt/beta-catenin signaling.' "The Wnt/beta-catenin signaling pathway controls key aspects of embryonic development and adult tissue homeostasis, including the formation and maintenance of bone. Recently, mutations in the OSTM1 gene were found to be the cause of severe autosomal recessive osteopetrosis in both the mouse and humans," scientists writing in the journal Cellular Signalling report.
"This disorder is characterized by increased bone mass resulting from a defect in osteoclast maturation. The possible role of OSTM1 in signaling of the...
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Source: Lab Business Week (2008-05-11)
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