Adverse Drug Reactions

Study findings from Sankyo Co., Ltd. provide new insights into adverse drug reactions

Published in Lab Business Week, October 25th, 2009

"The risk of idiosyncratic drug toxicity (IDT) is of great concern to the pharmaceutical industry. Current hypotheses based on retrospective studies suggest that the occurrence of IDT is related to covalent binding and daily dose," scientists in Hiromachi, Japan report.

"We determined the covalent binding of 42 radiolabeled drugs in three test systems (human liver microsomes and hepatocytes in vitro and rat liver in vivo) to assess the risk of IDT. On the basis of safety profiles given in official documentation, tested drugs were classified into the safety categories of safe, warning, black box warning, and withdrawn. The covalent binding in each of the three test...

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Source: Lab Business Week (2009-10-25)

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