University of South Florida
Topoisomerase II alpha foils the effectiveness of etoposide in myeloma cells
Published in Lab Law Weekly, June 25th, 2004
"In this study we have investigated the role of topoisomerase (topo) IIalpha trafficking in cellular drug resistance. To accomplish this, it was necessary to separate the influence of cell cycle, drug uptake, topo protein levels, and enzyme trafficking on drug sensitivity. Thus, we developed a cell model (called accelerated plateau) using human myeloma H929 cells that reproducibly translocates topo IIalpha to the cytoplasm," scientists in the United States report.
"Compared to log-phase cells, the cytoplasmic redistribution of topo IIalpha in plateau-phase cells correlated...
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Source: Lab Law Weekly (2004-06-25)
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