Channing Laboratories

Postsurgical fibrosis regulated by programmed death-1 inhibitory pathway

Published in Lab Law Weekly, June 25th, 2004

Formation of postsurgical adhesions is regulated by T-cell costimulation, so targeting these pathways may be a way to prevent such fibroses, researchers say.

"Surgical adhesions are a common and often severe complication of abdominal or pelvic injury that cause pelvic pain, bowel obstruction, and infertility in women. Current treatments are of limited effectiveness because little is known about the cellular and subcellular processes underlying adhesiogenesis," wrote M.A. Holsti and colleagues, Channing Laboratories, Boston, Massachusetts.

"Recently, we showed that Th1 alphabeta CD4+ T cells mediate the pathogenesis of adhesion formation in a rodent...

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Source: Lab Law Weekly (2004-06-25)

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