Tokyo Medical University

Hypoxia-inducible factor-1 transactivates TGF-beta3 in trophoblast

Published in Lab Law Weekly, October 29th, 2004

According to a report from Tokyo Medical University researchers, "Hypoxia occurs during the development of placenta in the first trimester and is implicated in trophoblast differentiation.

"Intervillous blood flow increases after 10 weeks of gestation and results in exposure of trophoblast cells to oxygen. Before this time, low oxygen appears to prevent trophoblast differentiation toward an invasive phenotype," wrote H. Nishi and colleagues.

"The oxygen-regulated early events of trophoblast differentiation are mediated by transforming growth factor (TGF)-beta3. TGF-beta3 plays a vital role in trophoblast differentiation, and its overexpression can be...

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Source: Lab Law Weekly (2004-10-29)

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