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Autonomous University of Barcelona

Knockout mice show interleukin-6 helps the brain cope with injury

Published in Lab Law Weekly, March 25th, 2005

Knockout mice show interleukin-6 helps the brain cope with injury.

"Traumatic injury to the brain is one of the leading causes of injury-related death or disability. Brain response to injury is orchestrated by cytokines such as interleukin (IL)-6, but the full repertoire of responses involved is not well known. We here report the results obtained with microarrays in wild-type and IL-6 knockout mice subjected to a cryolesion of the somatosensorial cortex and killed at 0, 1, 4, 8 and 16 days post-lesion," scientists in Spain report.

"Overall gene expression was analyzed by using Affymetrix genechips/oligonucleotide arrays with approximately 12,400...

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