University of Bristol

Puberty accelerates development of type 1 diabetes in IL6-174CC females

Published in Lab Law Weekly, June 10th, 2005

Puberty appears to be an accelerator of type 1 diabetes in IL6-174CC females.

"The pubertal peak in onset of type 1 diabetes occurs earlier in girls than boys. We postulated that this sex difference might be mediated in part by estrogen or by genes regulated by estrogen, such as the interleukin-6 (IL6) gene. Previous studies concerning the role of an estrogen-sensitive single nucleotide polymorphism (SNP) in the IL6 promoter in type 1 diabetes have proved contradictory. We therefore selected a large, genetically homogenous population-based cohort, analyzed by age at onset and sex, to test the hypothesis that the IL6-174G > C SNP affects age at onset of type 1...

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Source: Lab Law Weekly (2005-06-10)

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