Peking University, Beijing

Reduced folate carrier gene raises the risk for neural tube defects

Published in Lab Law Weekly, August 19th, 2005

Reduced folate carrier gene raises the risk for neural tube defects.

"There is a considerable body of data demonstrating that periconceptional supplementation of folic acid can prevent a significant proportion of neural tube defects (NTDs). At present, the mechanism by which folic acid exerts its beneficial effect remains unknown," scientists writing in the journal Birth Defects Research Part A - Clinical and Molecular Teratology report.

"Folate transporter genes, including the reduced folate carrier gene (RFC1), have been proposed as NTD risk factors. The study population included 104 nuclear families with NTDs and 100 nonmalformed control...

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Source: Lab Law Weekly (2005-08-19)

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