University of Illinois
Imidazenil antagonizes sedative but not anticonvulsant diazepam activity
Published in Lab Law Weekly, November 11th, 2005
"Flumazenil (FLU), a specific benzodiazepine (BZ) receptor antagonist, has been used in the treatment of acute BZ intoxication or the alleviation of BZ-induced withdrawal syndrome on the basis of its weak partial agonist action at GABAA receptors," pharmacologists in the United States explained. "However, given to patients, FLU can worsen diazepam-induced withdrawal syndrome by lowering seizure threshold."
J. Anta and colleagues at the University of Illinois "therefore investigated whether imidazenil, a selective positive allosteric modulator of GABA action at...
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Source: Lab Law Weekly (2005-11-11)
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