University of Alberta

Single transmembrane domain IGF-II/M6P receptor activates G-protein, PKC-dependent pathway

Published in Lab Law Weekly, March 10th, 2006

Single transmembrane domain insulin-like growth factor-II/mannose-6-phosphate receptor regulates central cholinergic function by activating a G-protein-sensitive, protein kinase C-dependent pathway.

"The insulin-like growth factor-II/mannose-6-phosphate (IGF-II/M6P) receptor is a single-pass transmembrane glycoprotein that plays an important role in the intracellular trafficking of lysosomal enzymes and endocytosis-mediated degradation of IGF-II. However, its role in signal transduction after IGF-II binding remains unclear," investigators in Canada report.

"In the present study," explained C. Hawkes and colleagues, University of Alberta, "we report...

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Source: Lab Law Weekly (2006-03-10)

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