Pharmacology

Investigators at Novartis target pharmacology

Published in Lab Law Weekly, May 25th, 2007

Research findings, "Effect of clopidogrel on the steady-state pharmacokinetics of fluvastatin," are discussed in a new report. "This study assessed the effects of clopidogrel, a CYP 2C9 inhibitor, on fluvastatin pharmacokinetics in healthy volunteers. The effects of combined clopidogrel-fluvastatin treatment on platelet function were also determined," investigators in the United States report.

"Subjects received 80 mg fluvastatin (extended-release formulation) alone on days 1 through 9, 80 mg fluvastatin and 300 mg clopidogrel (loading dose) on day 10, and 80 mg fluvastatin and 75 mg clopidogrel (maintenance dose) on days 11 through 19. Compared to treatment with...

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Source: Lab Law Weekly (2007-05-25)

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