Thrombosis Prevention
New thrombosis prevention study findings reported from Bristol-Myers Squibb Company
Published in Lab Law Weekly, August 24th, 2007
A new study, "Biomarker optimization to track the antithrombotic and hemostatic effects of clopidogrel in rats," is now available. According to a study from the United States, "We determined the dose response of the ADP antagonist clopidogrel (0.3-50 mg/kg p.o.) in rat models of thrombosis and provoked bleeding and correlated these activities to ex vivo platelet activation. Carotid artery thrombosis was induced by FeCl(2)."
"Bleeding time was measured by mesenteric vessel puncture and renal cortex or cuticle incision. Platelet biomarkers included standard ADP-induced aggregation, P2Y(12) receptor occupancy, and phosphorylation of vasodilator-stimulated phosphoprotein....
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Source: Lab Law Weekly (2007-08-24)
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