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Renal function improves in pediatric liver transplant by switch in monitoring

Published in Law and Health Weekly, January 12th, 2004

In pediatric as well as adult liver transplant recipients, switching to 2-hr cyclosporine post-dose monitoring improves renal function.

According to recent research from Israel, "in adult liver transplant recipients, 2-h post-Neoral (C2) dose monitoring is associated with a lower incidence and severity of acute cellular rejection and improved renal function than C0 (trough level) monitoring.

"This study examined whether switching from C0 to C2 monitoring during maintenance also improves renal function in pediatric liver transplant recipients. Three boys aged 11-16 yr with stable graft function at 6-50 mo after liver transplantation were switched from...

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