National Chemical Laboratory, Maharashtra
New steroidal dimers are antifungal and inhibit human oral and breast cancer
Published in Law and Health Weekly, May 1st, 2004
"Bile acid-derived novel amphiphilic topology was designed and synthesized in the form of steroidal dimers," wrote scientists in the Journal of Medicinal Chemistry.
"These dimers were tested for antifungal and antiproliferative activity in vitro. N-1,N-3-Diethylenetriaminebis[cholic acid amide] was found to be active against C. albicans, Y. lipolytica, and B. poitrassi at nanomolar concentration and did not show any effect on cell proliferation," reported D.B. Salunke and colleagues.
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