Published in Law and Health Weekly, May 8th, 2004
"Vascular integrins are essential regulators and mediators of physiological and pathological angiogenesis, including tumor angiogenesis. Integrins provide the physical interaction with the extracellular matrix (ECM) necessary for cell adhesion, migration and positioning, and induce signaling events essential for cell survival, proliferation and differentiation. Integrins preferentially expressed on neovascular endothelial cells, such as alpha(V)beta(3) and alpha(5)beta(1), are considered as relevant targets for antiangiogenic therapies," investigators in Switzerland report.
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