Institute for Research in Biomedicine, Bellinzona
Cord blood cell-transplanted mice develop functional human immune system
Published in Law and Health Weekly, May 29th, 2004
"Because ethical restrictions limit in vivo studies of the human hematolymphoid system, substitute human to small animal xenotransplantation models have been employed. Existing models, however, sustain only limited development and maintenance of human lymphoid cells and rarely produce immune responses," wrote investigators in Switzerland.
"Here we show that intrahepatic injection of CD34+ human cord blood cells into conditioned newborn Rag2(-/-) gamma(c)(-/-) mice leads to de novo development of B, T, and dendritic cells; formation of structured primary and secondary lymphoid...
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