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Beausejour Medical Research Institute
RT-PCR for mammaglobin genes detects sentinel lymph nodes micrometastases
June 26th, 2004
A molecular assay for mammaglobin genes can be used to detect lymph node micrometastases in breast cancer patients. In a recent study, scientists in Canada "examined the expression of the mammaglobin genes, MGB1 and MGB2, in the sentinel lymph nodes (SLNs) of patients with breast cancer and compared our results with the histologic status of the same SLNs." "Compared with immunohistochemical staining for cytokeratin 8, which detected metastases in 17 of 42 patients, reverse transcription-polymerase chain reaction (RT-PCR) for MGB1 or MGB2 genes was positive in 22 patients," reported R.J. Ouellette and coauthors at the...
Source: Law & Health Weekly (2004-06-26)
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