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Abbott Laboratories

Non-imidazole histamine receptor antagonist has anti-obesity effects

"Histamine affects homeostatic mechanisms, including food and water consumption, by acting on central nervous system (CNS) receptors. Presynaptic histamine H₃ receptors regulate release of histamine and other neurotransmitters, and histamine H₃ receptor antagonists enhance neurotransmitter release. A-331440 {4'-[3-(3(R)-(dimethylamino)-pyrrolidin-1-yl)-propoxy]-biphenyl-4-carbonitrile} is a histamine H₃ receptor antagonist which binds potently and selectively to both human and rat histamine H-3 receptors (K_i {{<=}}25 nM),"...

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