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Albert Einstein College of Medicine
Nck and Crk adaptor proteins modulate VEGF-controlled cell migration
June 26th, 2004
Nck and Crk adaptor proteins modulate VEGF-controlled cell migration. According to researchers in the United States, "we have asked whether the Nck and Crk adaptor proteins play important roles in the vascular endothelial growth factor (VEGF)induced signaling pathways that lead to an enhancement in cell migration. The introduction into human umbilical vein endothelial cells of a dominant-negative inhibitor for either Nck or Crk blocked the recruitment of both endogenous proteins to the KDR VEGF receptor subtype indicating that both proteins are recruited to the same docking site. The Nck and Crk dominant-negatives led to the formation of abnormally large focal adhesion,...
Source: Law & Health Weekly (2004-06-26)
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