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Emory University

Aprotinin is safe and effective in cardiac surgery

Published in Law and Health Weekly, September 4th, 2004

Aprotinin cuts blood loss and reduces the need for transfusions in cardiac surgery.

"Cardiac surgery and cardiopulmonary bypass produces bleeding and the need for allogenic blood product transfusions in many patients. Blood conservation is important in the perioperative management of patients," scientists writing in the journal Orthopedics report.

"Aprotinin, a serine protease inhibitor isolated from bovine lung, is a complex protease inhibitor that is an antifibrinolytic, inhibits contact activation, and decreases the inflammatory response to cardiopulmonary bypass," wrote J.H. Levy and colleagues, Emory University, School of Medicine.

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