Published in Law and Health Weekly, October 23rd, 2004
"Potential problems of conventional transgenes include insertional disruption of the host genome and unpredictable, irreproducible expression of the transgene by random integration. Alternatively, human artificial chromosomes (HACs) can circumvent some of the problems. Although several HACs were generated and their mitotic stability was assessed, a practical way for introducing exogenous genes by the HACs has yet to be explored," investigators in Japan report.
"In this study, we developed a novel HAC from sequence-ready human chromosome 21 by telomere-directed chromosome truncation and...
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