University of North Carolina

CF-KO murine model useful for study of altered drug clearance

Published in Law and Health Weekly, October 23rd, 2004

The CF-KO murine model appears to be suitable for the study of altered drug disposition in cystic fibrosis (CF).

"The cftr^tm1Unc-knockout (CF-KO) mouse is being evaluated as a model of increased drug clearance noted clinically" in CF patients," scientists in the United States explained.

In their study, M.N. Tallman and coauthors at the University of North Carolina "investigated whether CF-KO mice exhibited altered omeprazole pharmacokinetics compared with wild-type mice."

"Clinical observations have suggested reduced responses to omeprazole in CF children, which may reflect alterations in bioavailability or...

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Source: Law and Health Weekly (2004-10-23)

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