University of Tokyo
Therapy targeting interleukin-13 may be able to suppress fibrotic growth
Published in Law and Health Weekly, December 4th, 2004
"Interleukin (IL)-13 is a novel lymphokine produced by activated type 2 helper cells. In this study, we examined the target genes of IL-13 by the cDNA microarray analysis in human dermal fibroblasts. We focused on the human alpha2(I) collagen gene, which was one of the IL-13-induced genes by the microarray analysis," investigators in Japan report.
"IL-13 induced type I collagen protein as well as mRNA in a dose-dependent manner. Actinomycin D, an RNA synthesis inhibitor, significantly blocked the IL-13-mediated up-regulation of alpha2(I) collagen mRNA expression, whereas...
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