Eli Lilly & Co.

Simultaneous activation of JNK and p38 by MLK7 may affect cardiac decompensation

Published in Law and Health Weekly, December 11th, 2004

Transgenic mice with cardiac-specific over-expression of MLK7 have increased mortality when exposed to chronic beta-adrenergic stimulation.

According to recent research from the United States, "Mixed lineage kinase 7 (MLK7) is a recently identified mitogen-activated protein kinase kinase kinase with enriched expression in skeletal muscle and heart. When over-expressed in cardiac myocytes, MLK7 activates both the p38 and c-Jun N-terminal kinase (JNK) stress-activated pathways and induces a cellular phenotype characteristic of cardiac hypertrophy, including a fetal gene expression pattern and increased protein synthesis. We sought to determine the effect of MLK7 on...

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Source: Law and Health Weekly (2004-12-11)

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