Published in Law and Health Weekly, January 1st, 2005
"Lansoprazole is a substrate of CYP2C19 and CYP3A4," scientists in Japan explained.
N. Yasui-Furukori and colleagues at Hirosaki University conducted a study "to compare the inhibitory effects of fluvoxamine, an inhibitor of CYP2C19, on the metabolism of lansoprazole between CYP2C19 genotypes."
"Eighteen volunteers -- of whom six were homozygous extensive metabolizers (EMs), six were heterozygous EMs, and six were poor metabolizers (PMs) for CYP2C19 -- received three 6-day courses of either daily 50 mg fluvoxamine or placebo in a...
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