Univ. of California, San Diego

Immunostimulatory DNA reverses airway scarring, inflammation

Published in Law and Health Weekly, January 1st, 2005

The structural changes, including airway scarring and inflammation, that contribute to severe breathing problems associated with asthma were significantly reversed in mice treated with immunostimulatory sequences of DNA (ISS), a novel therapy developed by researchers at the University of California, San Diego (UCSD) School of Medicine.

Published in the December 15, 2004, issue of the Journal of Immunology, the study demonstrated that systemic administration of ISS to mice with scarred and inflamed airways significantly reduced the degree of blockage and scarring. The researchers also determined the specific mechanisms used by ISS to reverse structural changes...

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Source: Law and Health Weekly (2005-01-01)

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