Shanghai Second Medical University
Effects of H. pylori VacA on tumor gene expression determined
Published in Law and Health Weekly, January 8th, 2005
"To understand the biological processes within host cells induced by VacA," the isogenic H. pylori strains NCTC 11638 and 11638-DeltavacA "were used to stimulate gastric cancer cells SGC7901, and differentially expressed genes in host cells were identified using cDNA microarray technology."
"More than 300 genes were found to alter their mRNA expression at different time points, among which 68 were related to the cytoskeleton, [and] 87 were associated with cell cycle, cell death and proliferation," reported J.P. Yuan and coauthors...
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