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University of Erlangen Nurnberg

SIVmac239/HIV-2ROD Vpx proteins interact with alpha-actinin 1

Published in Law and Health Weekly, January 22nd, 2005

SIVmac239/HIV-2ROD Vpx proteins interact with alpha-actinin 1

According to a study from Germany, "Vpx genes of human immunodeficiency virus type 2 (HIV-2) and immunodeficiency viruses from macaques (SlVmac), sooty mangabeys (SIVsm) and red-capped mangabeys (SIVrcm) encode a 112 aa. protein that is packed into virion particles via interaction with the p6 domain of p55(gag).

"Vpx localizes to the nucleus when expressed in the absence of other viral proteins. Moreover, Vpx is necessary for efficient nuclear import of the pre-integration complex (PIC) and critical for virus replication in quiescent cells, such as terminally differentiated macrophages and...

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